Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice.
Increased superoxide is thought to play a major role in vascular dysfunction in a variety of disease states. Superoxide dismutase (SOD) limits increases in superoxide; however, the functional significance of selected isoforms of SOD within the vessel wall are unknown. We tested the hypothesis that selective loss of CuZnSOD results in increased superoxide and altered vascular responsiveness in C...
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OBJECTIVE Aging is associated with increased oxidative stress levels and impaired neovascularization following ischemia. CuZnSOD has an important role to limit oxidative stress in the vasculature. Here we investigated the role of CuZnSOD for the modulation of ischemia-induced neovascularisation during aging. METHODS AND RESULTS Hindlimb ischemia was surgically induced in young (2- month-old) ...
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BACKGROUND AND PURPOSE Hyperhomocysteinemia is an emerging risk factor for stroke, but little is known about effects of hyperhomocysteinemia on cerebral vascular function. We tested the hypothesis that chronic hyperhomocysteinemia in mice causes endothelial dysfunction in cerebral arterioles through a mechanism that involves superoxide. METHODS Mice heterozygous for a targeted disruption of t...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000043280.65241.04